Family: Oto-Manguean (56 languages)

 Genus: Amuzgoan
Amuzgo
 Genus: Chichimec
Chichimeca-Jonaz
 Genus: Chinantecan (7 languages)
Chinantec (Comaltepec)
Chinantec (Lealao)
Chinantec (Palantla)
Chinantec (Quiotepec)
Chinantec (San Felipe Usila)
Chinantec (Sochiapan)
Chinantec (Tepetotutla)
 Genus: Mixtecan (18 languages)
Cuicatec
Mixtec (Alacatlatzala)
Mixtec (Atatlahuca)
Mixtec (Ayutla)
Mixtec (Chalcatongo)
Mixtec (Chayuco)
Mixtec (Coatzospan)
Mixtec (Jamiltepec)
Mixtec (Jicaltepec)
Mixtec (Molinos)
Mixtec (Ocotepec)
Mixtec (Peñoles)
Mixtec (San Juan Colorado)
Mixtec (San Miguel el Grande)
Mixtec (Silacayoapan)
Mixtec (Yosondúa)
Trique (Chicahuaxtla)
Trique (Copala)
 Genus: Otomian (6 languages)
Mazahua
Ocuilteco
Otomí (Ixtenco)
Otomí (Mezquital)
Otomí (Santiago Mexquititlan)
Otomí (Sierra)
 Genus: Pamean
Pame
 Genus: Popolocan (7 languages)
Chocho
Ixcatec
Mazatec (Chiquihuitlán)
Mazatec (Huautla)
Popoloca (Metzontla)
Popoloca (San Juan Atzingo)
Popoloca (San Vicente Coyotepec)
 Genus: Subtiaba-Tlapanec
Tlapanec
 Genus: Zapotecan (14 languages)
Chatino (Nopala)
Chatino (Sierra Occidental)
Chatino (Tataltepec)
Chatino (Yaitepec)
Zapotec (Isthmus)
Zapotec (Ixtlan)
Zapotec (Juárez)
Zapotec (Mitla)
Zapotec (Mixtepec)
Zapotec (Quiegolani)
Zapotec (San Lucas Quiaviní)
Zapotec (Texmelucan)
Zapotec (Yatzachi)
Zapotec (Zoogocho)